Estimate the extent of etiologic heterogeneity 


Estimate the incremental explained risk variation in a casecontrol study 

Estimate the incremental explained risk variation in a caseonly study 

Test for etiologic heterogeneity 

Test for etiologic heterogeneity of risk factors according to disease subtypes in a casecontrol study 

Test for etiologic heterogeneity of risk factors according to individual disease markers in a casecontrol study 

Identify optimal D solution 

Obtain optimal D solution based on kmeans clustering of disease marker data in a casecontrol study 

Obtain overall pvalue for factor variable 

Posthoc test to obtain overall pvalue for a factor variable used in a


Example DatasetsSimulated data to illustrate package use 

Simulated subtype data 